Factors Associated with Thrombosis in Hospitalized COVID Patients

Introduction: COVID infection is associated with increased risk of venous thromboembolism (VTE). Incidence rates as high as 17-20% have been reported in hospitalized patients. We wanted to evaluate the incidence of Thrombosis in COVID patients admitted to Augusta University and evaluate factors which would be associated with this risk in hospitalized patients.

Method: We looked at patients admitted to Augusta University from January 1^st 2020 through August 31^st 2020 and collected following information about these patients.

Presence or absence of a blood clot during hospitalization (Included patients with Deep Vein Thrombosis, Pulmonary Embolism, unusual site of thrombosis, stroke or myocardial infarction), Age, Gender, Race, Length of Stay, ICU stay, Intubation status, addiction history, different medications patients were on prior to admission, CBC with differential, reticulocyte count, Haptoglobin, PT / INR, PTT, Fibrinogen, Albumin, D-dimer, Liver function test, Ferritin, Troponin level, LDH, Arterial Blood Gas results and ABO blood group.

We performed univariate (Chi-squared test and student's t-test) of the data collected to see which of the variables were significantly associated with developed of thrombosis in hospitalized COVID patients.

The variables significantly associated with thrombosis were then plugged in a logistic regression model to evaluate which variables were significantly associated with thrombosis development on a multivariate analysis.

Result: We looked at 332 patients, of whom, 29 patients has thrombosis and 303 did not, with 9.4% risk of thrombosis, significantly higher than 4% per 100 patient year baseline population risk.

Length of Hospital stay (p-0.01), ICU admission (p-0.0002), endotracheal intubation (p-0.04), presence of psychoactive medications (p-0.01), Hemoglobin level (p-0.04), Albumin level (p-0.03) and D-dimer level (p-0.01) were significantly associated with thrombosis on univariate analysis. Chi Square test results for other parameters in attached table.

ICU admission during hospitalization (p-0.02), hemoglobin level (p-0.08), D-dimer level (p-0.05) and presence of psychoactive medications (p-0.09) were significantly associated with thrombosis on multivariate correlation and regression analysis.

Conclusion: ICU admission, elevated hemoglobin level, elevated D - dimer and presence of psychoactive medication were significantly associated with development of thrombosis in patients hospitalized for COVID infection, at Augusta University.

Kutlar:Forma Therapeutics, Inc.: Honoraria, Research Funding; Guidepoint Consulting Services: Consultancy, Honoraria; ORIC Pharmaceuticals, Inc.: Consultancy, Honoraria; Novartis Pharmaceuticals: Consultancy, Honoraria, Research Funding; PeerView Institute: Honoraria; Novo Nordisk Pharmaceuticals: Honoraria, Research Funding; Graphite Bio Inc.: Consultancy, Honoraria; bluebird bio Inc.: Consultancy, Honoraria; Vertex Pharmaceuticals, Inc.: Consultancy, Honoraria; Global Blood Therapeutics: Consultancy, Honoraria, Research Funding, Speakers Bureau; American Society of Hematology: Consultancy, Honoraria, Research Funding; Eradigm Consultancy: Honoraria; MJH Life Sciences: Honoraria.